As the cutoff is made more stringent from “no cutoff” (all possible templates considered) to 10 0 (all templates with e-value better than 1.0 are excluded), the average number of Smotifs in the dynamic database (right Y-axis) decreases by 50% (from 1684.05 to 826.95) and the average e-value of the best hit in the dynamic database (left Y-axis) increases from barely significant to a random hit value (from 0.006 to 1.225), indicating the gradual loss of reliable templates.
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Modularity of Protein Folds as a Tool for Template-Free Modeling of Structures.
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