However, considering the short gestation in rats (22.5 days) and mice (19.5 days), and their consequently faster brain development, compared to the relatively long human gestation (280 days), there may be significant differences in the effect of a pharmacological intervention aimed at crucial brain-development-mediating elements such as NMDA receptors.
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Propofol administration to the maternal-fetal unit improved fetal EEG and influenced cerebral apoptotic pathway in preterm lambs suffering from severe asphyxia.
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