Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.

Comparisons of AID-dependent Nbs1-binding sites with results from other genome-wide studies Approximately 25% of the AID-dependent DSBs correspond to previously-identified AID-binding sites in cells induced to switch with LPS+IL-4 [ 16 ], and the correspondence is highly significant compared with random sequences ( Table 1 ).

also in 132,142 other papers