Singlet oxygen treatment of tumor cells triggers extracellular singlet oxygen generation, catalase inactivation and reactivation of intercellular apoptosis-inducing signaling.

The Yates continuity corrected chi-square test was used for the statistical determination of significances ( p <0.01=significant; p <0.001=highly significant). 4 Results Illumination of murine fibrosarcoma cells that had been loaded with the photosensitizer photofrin for 2.5 h caused massive cell death independent of the original density of the cells.

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