Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19(ARF)/p53 axis in hematopoiesis, early T-cell development and tissue differentiation.

Of note, among the pro-apoptotic genes of interest, in particular highly significant increases in p19 ARF mRNA of up to 100-fold were detectable in total Mysm1-deficient thymocytes from 4-week-old mice compared with their wild-type controls ( Figure 3a , right).

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