Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules.

It should be noted that the changes in kinetics and force due to HCM and DCM mutations are often very small (in the 10–50% range) but highly significant; thus, small differences between large animals, such as porcine, will be extremely important in the context of HCM and DCM, and it is critically important to use the very same protein as in this work.

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