A number of other associated loci have also been reported by further association with disease severity, IgE, or concurrent asthma, namely 3p26-24, 3q14, 4p15-14, 13q14, 15q14-15, 17q21, 18q11-12, 18q21 and 20.[ 23 , 24 ] A polymorphism in the gene encoding the chain of the high affinity IgE receptor FCR1 has demonstrated a highly significant association with atopic dermatitis.[ 25 ] Genes on chromosome 5q encoding the cytokine gene cluster have been linked to atopic mucosal syndrome[ 26 ] and include associations with polymorphisms in the Interleukin 4 (IL-4) gene with atopic dermatitis.[ 27 , 28 , 29 , 30 ] A gene at 16p11.2-12 encodi
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