Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer.

A highly significant reduction of the number of HIF-1α-positive cells in tumor sections was observed from 5 to 7 days of treatment ( P < 0.0001) but returned to the control value at 9 days suggesting a transient effect of the anti-S1P mAb (Figure 2B ).

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