Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis.

We recognize that the association between maternal non-transmitted haplotype score and gestational age was only modestly significant (meta p = 0.0424), and it was mainly driven by the DNBC cohort ( p = 0.018) and was not significant in the other two cohorts.

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There was also a marginally significant correlation between the estimated effect size of these SNPs on birth length and the reported effect size on adult height (Pearson’s ρ = 0.073, p = 0.055).

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Given the highly significant association between fetal genetic score based on adult height-associated SNPs with both birth length and birth weight, we further examined single SNP associations of these adult height-associated SNPs with both birth length and birth weight in the infants.

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