The Power Decoder Simulator for the Evaluation of Pooled shRNA Screen Performance.

22 We performed a Kolmogorov-Smirnov test on each screen/model pair, and, as anticipated, received highly significant p values for both Screen 100_2x and Screen 500_2x, indicating that the modeled and experimental distributions are perceptibly different.

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For screens with high overall power (Screen 100_4x and Screen 500_2x), we observe a slight trend toward higher power in detecting enriched hits than in detecting depleted hits.

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