The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.

These findings of higher K/T ratios and higher pro-inflammatory activity in our population compared to populations from developed countries, coupled to the highly significant positive associations found between the K/T ratios and inflammatory activity, especially IFN-γ (neopterin: r = 0.514; p < 0.0001; IL-6: r = 0.354; p = 0.0007; IFN-γ: r = 0.344; p = 0.001), and the negative associations between IFN-γ and tryptophan ( r = −0.217; p = 0.036), strongly suggest higher levels of inflammatory activity, leading to a higher rate of tryptophan oxidation in the kynurenine pathway, to be a major contributor to the lower tryptophan levels found in the black, low income, sub-Saharan population of this study than in HIV/AIDS populations from developed countries.

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The difference in quinolinic acid levels between the HAART (4.03 ± 2.04 μmol/l) and the HAART-naïve groups (5.77 ± 2.65 μmol/l) bordered on significance ( p = 0.072).

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