Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells.

Clin Epigenetics · 2015 · PMC4545913 · PMID 26300989

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highly significantno p-value reported

Encouragingly, treatment of MDA-MB-231 cells with HKMTI-1-005 resulted in highly significant upregulation of these consensus EZH2-repressed genes (Fig. 4a ).

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