In contrast, a decreasing trend has been observed in Japan among women younger than 50 years of age, whereas an increasing trend has been observed among women older than 60 years of age ( Yoshiike et al. , 2002 ).
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Comparison of plasma levels of obesity-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA.
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Plasma levels of C-peptide and leptin were significantly different between the populations, with Japanese in Tokyo having the lowest mean, followed by Japanese Brazilians and Japanese Americans, although the difference was of borderline significance for C-peptide between Japanese in Tokyo and Japanese Brazilians.