highly significantP <0.001
With the wild-type TRβ/RXRα heterodimer, 9cRA impaired T3-mediated induction of a TR-responsive luciferase reporter in CV-1 mammalian cells transfected with TRβ/RXRα, shown by a highly significant effect of 9cRA in a two-way analysis of variance (ANOVA, F(1,42)=27; P <0.001).