Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana.

The RNA-seq based estimates of the change in transcript abundance showed a highly significant positive correlation with the change in the long/short-ratio ( Fig 2B ; correlation coefficient 0.32; p-value <1.0E-50), which was even stronger for the 97 genes with significant tail-length change after multiple-testing correction ( Fig 2B ; correlation coefficient 0.4; p-value = 4.4E−05), suggesting that changing the poly(A)-tail length due to reduced PAPS1 activity alters transcript abundance.

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