An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12.

Wouldn't it be more precise to address the different stage of CD8 + T cell differentiation instead? Although the observations reported here depart from the accepted notion about CXCR3 expression on effector CD8 + T cells, these results may be significant for responses generated by protozoan parasites.

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