The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity.

Consequently, though not statistically significant (p = 0.079), the plasma levels of adiponectin exhibited a possible trend toward significance in the EP4 agonist–treated group ( Fig 5B ), suggesting that polarization of ATMs toward the anti-inflammatory M2 phenotype balanced adipokine secretion and improved insulin sensitivity in obese mice.

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