Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD).

Applying a low- or high-stringency filter for statistically significant DEGs prior to modeling in BMDExpress significantly decreased the means of each group of BMD(L) values for both RNA-seq and microarray datasets, as shown in Fig 2 ; the results of the t-tests were extremely significant, with p-values being less than 0.0001 for all comparisons ( S5 Table ).

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