Although there was a marginally significant increase in total IgE levels with malaria infection, it was not possible to corroborate whether this was due to polyclonal induction of IgE antibodies during malaria infection [ 49 – 51 ] or changes in specific anti-malarial IgE.
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Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.
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The sentences
Thirdly, the p-values for each HbAS-antibody association were similar and highly significant even after adjusting for multiple testing.