Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways.

J Exp Clin Cancer Res · 2015 · PMC4553001 · PMID 26245871

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highly significantno p-value reported

The P-value of < 0.05 was considered statistically significant, p < 0.01 was considered statistically highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.