Genetic polymorphisms of PAI-1 and PAR-1 are associated with acute normal tissue toxicity in Chinese rectal cancer patients treated with pelvic radiotherapy.

A positive and significant association was found between PAI-1 rs2227631 and fecal incontinence (adjusted OR=3.172, 95% CI=1.490–6.751, P =0.003 for GG versus AA; and adjusted OR=2.541, 95% CI=1.249–5.170, P =0.010 for AG/GG versus AA), and borderline significance was shown for one variant allele (adjusted OR=2.108, 95% CI=1.001–4.440, P =0.05 for AG versus AA).

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In both dominant and recessive models for PAI-1 rs1050955, a protective borderline significant association with incontinence was observed (adjusted OR=0.606, 95% CI=0.342–1.075, P =0.087 for AG/GG versus AA in a dominant model, and adjusted OR=0.620, 95% CI=0.383–1.006, P =0.053 in a recessive model).

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