Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions.

12 Although we do not know whether the loss of imprinting or altered methylation states of this gene cluster might contribute to their activation, a highly significant correlation between the Igf2 mRNA and H19 mRNA levels in the tumors suggests that their transcriptional activation is mediated by common enhancers. 13 Increased mRNA expression of IGF2 and H19 , as well as a significant correlation of their mRNA expression levels, have been shown in human HCC. 22 – 25 However, following a partial hepatectomy in rodents, whereas H19 mRNA is markedly induced, Igf2 mRNA expression is not activated, 26 indicating a striking contrast between non-transformed and transformed hepatocytes.

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