highly significantp < 0.001
Compared to sham mice, the levels of serum creatinine were significantly increased at all three time points in IR-injured WT and KO mice and the differences in the means of serum creatinine were highly significant among all different groups of WT mice ( p < 0.001), KO mice ( p < 0.001), or all groups from both WT and KO ( p < 0.001), as indicated by one-way analysis of variance (ANOVA).