Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension.

PLoS One · 2015 · PMC4564187 · PMID 26352810

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closest p · 0.0× alpha

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boldest claim

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highly significantp = 0.0001actually significant

For the 1 mg/kg dose group, IL-6 levels were inhibited by >95%, which was highly significant compared to either the TNF-α only or negative control dAb (DMS5538) group, p = 0.0001 or p = 0.001, respectively.

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