Trends of non-union and prescriptions for non-steroidal anti-inflammatory drugs in the United States, 1993-2012.

In addition, the time trend was also significant, reflecting a decreasing trend in non-unions after withdrawal of specific COX-2 inhibitors compared to the period of their prevalent use (p < 0.001) ( Table 2 ).

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However, the time trend since introduction of COX-2 selective inhibitors was significant, indicating an increasing trend during prevalent use of COX-2 selective inhibitors relative to the baseline period ( Figure 6 ).

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