Barely Significant
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Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne: the ACTUO observational prospective multicenter cohort trial in 643 patients.

BMC Dermatol · 2015 · PMC4567797 · PMID 26361978

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may be significantno p-value reported
The effect of the scarring may be notable and the functional, social and emotional impact on the patient’s quality of life may be significant [ 4 , 5 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.