Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data.

The application of the t -test (see Section 2 ) for distributions of SNP content showed that the differences between datasets All TFs , Chr_Mod , and three out of four subclasses of genes encoding TFs ( HTH, Basic, and Other ) versus genes from the whole-genome dataset were highly significant for the broad range of thresholds ( Figure 6(b) ).

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