Chronic Lead Exposure and Mixed Factors of Gender×Age×Brain Regions Interactions on Dendrite Growth, Spine Maturity and NDR Kinase.

PLoS One · 2015 · PMC4569283 · PMID 26368815

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0.0600

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marginally significantP = 0.06so close (0.05 < p ≤ 0.1)

In female hippocampus, Pb exposure significantly decreased NDR1/2 expression at PND30 (control, 1.480±0.020; Pb exposure, 1.077±0.096, F(1,6) = 16.899, P<0.01, n = 8), PND90 (control, 1.541±0.035; Pb exposure, 1.215±0.080, F(1,6) = 14.000, P<0.01, n = 8), and induced marginally significant decrease at PND60 (control, 1.355±0.080; Pb exposure, 1.105±0.111, F(1,6) = 3.358, P = 0.06, n = 8) ( Fig 7C ).

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