highly significantP < 0.01
Strikingly, mutant cells showed a highly significant ( P < 0.01, Kolmogorov–Smirnov test) decrease of ribosome density at specific codons (Figs 6 C and D and EV5 ), corresponding to all three Dnmt2 substrate codons Asp(GAC)/(GAU), Gly(GGC), and Val(GUU).