Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain.

First, although SNI and cuff produced similar early losses of NF200 and CGRP-IR fibres in the plantar paw, at 2 weeks SNI animals were almost significantly hyposensitive to mechanical stimuli and did not have cold hyperalgesia while cuff animals were hypersensitive to both mechanical and cold stimuli.

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