Effect of MDMA-Induced Axotomy on the Dorsal Raphe Forebrain Tract in Rats: An In Vivo Manganese-Enhanced Magnetic Resonance Imaging Study.

Comparison of SI max and the n coefficient obtained from each fitted curve between the MDMA and control groups using Student’s t- test ( Table 1 ) revealed significant decreases in SI max and n in the MFB ( p <0.05) and a nonsignificant trend toward lower SI max and n values in the VTA/IP in the MDMA group compared to the control group.

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First, given that the VTA is located in close proximity to the Mn 2+ injection site, the amount of Mn 2+ transported along the myelin sheath of nerve tract via passive diffusion may be significant and independent of axonal integrity.

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