Although absolute difference in pain outcomes between higher and lower doses was less than two points, the minimum important difference defined in the literature; the NPS score in the higher dose group was 50 % lower than that in the lower dose group, a difference which is considered clinically significant [ 38 ] especially given the fact that the comparison is made between two low means; therefore we do not expect to see a high absolute difference in scores despite the highly significant difference as a percentage.
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A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis.
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