However, in the post hoc analysis, according to histological subtypes, the mOS advantage provided by preoperative chemoradiotherapy was highly significant only for the squamous cell subtype (HR of 0.422 (95% CI 0.226–0.788)), while among adenocarcinomas the survival gain obtained by the addition of preoperative treatments did not achieve statistical significance (HR of 0.741 (95% CI 0.536–1.024)), suggesting that the difference between the study arms was driven by the squamous cell subtype despite this being the less numerous group.
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TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients.
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