Neoadjuvant trials in early breast cancer: pathological response at surgery and correlation to longer term outcomes - what does it all mean?

BMC Med · 2015 · PMC4578850 · PMID 26391216

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narrowly missed statistical significanceno p-value reported

In the event, Neo-ALLTO showed an absolute improvement of 20 % in pCR rates, and ALLTO narrowly missed statistical significance with an HR of 0.84 (97.5 %, CI 0.70–1.02), which was predicted to be HR 0.83 (Fig. 4 ), potentially owing to too few patients in the relevant comparisons.

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