marginally significantp < 0.10
To evaluate independent factors associated with NOSVA (time-dependent variable), significant or marginally significant univariate risk factors ( p < 0.10) recorded prior or at the time of the first episode of NOSVA, were examined using backward stepwise multivariate Cox proportional-hazards regression model; septic myocardial dysfunction and patient severity as assessed by SAPS II score at ICU admission were also included in the model; thus, the five variables included in the model were SAPS II score at ICU admission, age, septic myocardial dysfunction, renal and non-renal SOFA scores at day 1 of septic shock.