High-throughput transcriptomic analysis nominates proteasomal genes as age-specific biomarkers and therapeutic targets in prostate cancer.

Prostate Cancer Prostatic Dis · 2015 · PMC4579590 · PMID 25986914

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We found that high expression of five (PSMB4, PSMB7, PSMD14, PSMB2 and PSMD11) out of the top six genes ( Figure 4a ) were all associated with significantly worse 10-year metastatic rate in younger men, and the final gene PSMD6 showed the same trend with borderline significance ( Figures 4c–h ).

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