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YAP is closely correlated with castration-resistant prostate cancer, and downregulation of YAP reduces proliferation and induces apoptosis of PC-3 cells.

Mol Med Rep · 2015 · PMC4581809 · PMID 26126522

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an increasing trendno p-value reported
Based on the TNM staging, the samples in which YAP was present exhibited an increasing trend between T1 and T4.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.