Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models.

J Pharmacokinet Pharmacodyn · 2015 · PMC4582079 · PMID 26319673

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highly significantno p-value reported

For GABA A -receptor agonists, adenosine A 1 receptor agonists, (semi-) synthetic opioids and 5-HT 1A receptor agonists highly significant correlations were observed between the affinity and intrinsic efficacy estimates in vivo and corresponding estimates in in vitro bioassays confirming the validity of the approach [ 64 , 66 – 68 ].

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