Unlike β3-KO ECs, we noted only a small trend of increased VEGFR2 levels in β3-HET and β3-HET;NRP1Δcyto ECs ( Fig. 2 A).
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Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis.
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