Nanocurcumin Prevents Hypoxia Induced Stress in Primary Human Ventricular Cardiomyocytes by Maintaining Mitochondrial Homeostasis.

Nanocurcumin treatment was found to be highly significant in restoration of GSH/GSSG (129% vs 89% in curcumin, as shown in Fig 10A ) reduction in lipid peroxidation (70% vs 32% in curcumin) as shown in Fig 10B and reduction in excessive ROS leakage (38% vs 11% in curcumin) as shown in Fig 10C including restoration in xanthine oxidase activity (32% vs 18% in curcumin) as observed in Fig 10D and MnSOD activity (14.5% vs 6.3% in curcumin, as observed in Fig 10E ) in HVCM cells under hypoxia.

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