A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts.

Sci Rep · 2015 · PMC4585784 · PMID 26394925

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highly significantno p-value reported

These data indicated that, in spite of the highly significant vaccination activity of non-transduced cells in the CT26 model, irradiated FAP-expressing tumor cells were more efficacious than irradiated cells alone in eliciting anti-tumor immunity in multiple types of tumors.

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