Nitric oxide status in patients with chronic kidney disease.

Indian J Nephrol · 2015 · PMC4588324 · PMID 26628794

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an increasing trendno p-value reported

Further, the levels showed an increasing trend with advancing renal disease, with group-2 and group-3 patients having significantly higher levels when compared to patients in early stages of CKD (group-1).

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a decreasing trendno p-value reported

However, L-arginine in patients showed a decreasing trend that became statistically significant in group-3 consisting of patients in CKD stage 5.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.