Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.

Correlation between Genotype and Gene Expression The susceptibility allele (A) of the rs2872507 locus ( Figure 1 ) was associated with the reduced expression of Gasdermin B ( GSDMB ) in intestinal biopsies from patients with IBD; the associations for noninflamed ileum and noninflamed colon were significant and that for inflamed colon was borderline significant ( Table 2 , Figure 2 ).

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