Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

To see if whole tumour GREM1 expression correlated with this classification we used The Cancer Genome Atlas RNA-Seq data to match sporadic tumour samples to the published CCS1, CCS2 and CCS3 subtypes and found a highly significant correlation between high GREM1 expression and CCS3 subtype tumours ( P < 0.0001, ANOVA) ( Fig. 5d ).

also in 132,142 other papers