Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL.

The difference of resistance against starvation-induced cell death was highly significant with pIGFBP7 transfected Jurkat cells showing 85 % more proliferation measured by WST-1 signal on day four compared to the pCntrl cells ( P -value = 0.0006; Fig. 2b ).

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