Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.

Maternally-derived associations of this APOB SNP with borderline significance were also seen with fasting glucose and insulin levels in the combined results (combined p-value = 4.0x10 -3 and 7.4x10 -4 for glucose and insulin respectively), whereas no associations were observed with the paternally-derived allele ( Table 1 ).

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Our results showing a highly significant additive genetic effect of APOB rs1367117 on lipid traits and a highly significant maternal-specific effect on adiposity traits, in fact demonstrate why genetic associations studies overlooking POE conducted to date have typically identified associations of APOB gene variants with lipid traits but not with adiposity.

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