Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels.

In comparison the difference in CCR5 co-receptor expression levels failed to reach significance (Fig. 8 d) although the frequency of CCR5+ T cells and the MFI correlated with one another (Fig. 8 e).

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We found a highly significant correlation between the levels of FAS expression on CD4+ T cells prior to stimulation and the levels of apoptosis in HIV-1-infected T cells following stimulation with CD3/CD28 beads.

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