Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs.

While breakpoint remained unchanged, sulpiride administration did affect IR beam break rates, with a marginally non-significant decrease detected in the front zone of the chamber following administration of 10 mg/kg (main effect— F (2,34) = 3.82; p = 0.032; partial eta squared = 0.183; post hoc analysis (saline = 0.160 ± 0.014; 10 mg/kg sulpiride = 0.134 ± 0.011; p = 0.057)).

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In contrast, sulpiride had a marginally significant effect on the magazine IR beam break rate ( F (2,34) = 3.32; p = 0.048; partial eta squared = 0.163); however, post hoc analysis revealed no significant differences between the drug conditions (saline = 0.0133 ± 0.00491; 25 mg/kg sulpiride = 0.0201 ± 0.01486; 50 mg/kg sulpiride = 0.0175 ± 0.00979; p > 0.05 for all comparisons).

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