OspB was associated with significantly increased cell proliferation over 24–72 hrs following plating of the cells, with a slight trend apparent as early as 12 hrs, and this increase depended on IQGAP1 ( Fig 3C ).
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Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation.
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