Identifying the Role of E2 Domains on Alphavirus Neutralization and Protective Immune Responses.

However, serum from mice that were infected with chimeric viruses ΔDomA and ΔDomB did have a highly significant difference in variances (F test p<0.001) in neutralizing titers against SFV, indicating that both domains A and B are important for developing consistent neutralizing antibody responses.

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